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Heal the heart with innovative science.

We are a clinical-stage life sciences company focused on the research and clinical development of anti-inflammatory and anti-fibrotic therapies for the treatment of heart disease.

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Heart disease is a leading cause of death globally

We are dedicated to discovering novel therapeutic approaches that improve outcomes for patients suffering from underserved heart diseases.
Pericarditis
160,000
Prevalence of patients in the United States with pericarditis.
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Myocarditis
46,000
Incidence of myocarditis in the United States based on 14.4 cases per 100,000 persons.
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Heart Failure
8,000,000
Projected number of people living with heart failure in the United States by 2030.
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Therapeutic Areas

Our focus is to understand how inflammation and fibrosis contribute to diseases of the heart and to develop therapies, now in clinical trials for rare cardiac conditions, to target these mechanisms and promote healing.

A debilitating syndrome caused by inflammation of the thin fluid-filled sac surrounding the heart (the pericardium) characterized by sharp and stabbing chest pain, shortness of breath, and fatigue, resulting in physical limitations, reduced quality of life, emergency department visits, and hospitalizations.

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A debilitating syndrome caused by inflammation of the thin fluid-filled sac surrounding the heart (the pericardium) and is characterized by sharp and stabbing chest pain, shortness of breath, and fatigue, resulting in physical limitations, reduced quality of life, emergency department visits, and hospitalizations.

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An acute inflammatory disorder of the heart muscle (the myocardium) resulting in chest pain, impaired heart function, and heart rhythm irregularities, and is a leading cause of sudden cardiac death in people under 35 years of age.

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An acute inflammatory disorder of the heart muscle (the myocardium) resulting in chest pain, impaired heart function, and heart rhythm irregularities, and is a leading cause of sudden cardiac death in people under 35 years of age.

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A chronic, progressive syndrome in which the heart muscle is unable to pump enough blood to meet the body’s needs for blood and oxygen; symptoms include shortness of breath, rapid heart rate, and edema, resulting in reduced exercise capacity, limitations undertaking simple daily activities, and frequent hospitalizations.

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Diastolic heart failure, also referred to as heart failure with preserved ejection fraction (HFpEF), occurs when the heart loses its ability to relax normally (because the myocardium has become fibrotic and stiff) and cannot properly fill with blood during the resting period between each beat.

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Systolic heart failure, also referred to as heart failure with reduced ejection fraction (HFrEF), occurs when the heart loses its ability to contract normally and is unable to pump with sufficient force to push enough blood into circulation.

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View All Blog Posts
Blog A Woman's Decade-Long Battle Living with Chronic Recurrent Pericarditis and the Impact on Her Dream of Starting a Family

Stolina Qirjazi, a 33-year-old woman from Cleveland, Ohio, describes living with chronic recurrent pericarditis for over a decade and the limitations this condition has imposed on her life, “Be positive. Keep going. Everyday there is hope. Never give up. Never, never.”

October 2, 2023
Blog The Invisible Burden: Understanding the Full Impact of Recurrent Pericarditis

Rachel Freeburg, a resilient woman from Salem, Oregon, shares her story of battling the physical, mental, and financial hurdles of recurrent pericarditis for seven years: “I couldn’t even laugh because I was so exhausted; it rips you apart.”

September 6, 2023
Blog An Indomitable Spirit: A Battle Against Recurrent Pericarditis That Defies the Odds

Alexa Ritchie, 25, has spent the better part of a decade in a constant battle against a rare and debilitating illness that would change the course of her life forever: “It became routine that every couple of months I was down for 7  to 10 days.”

May 30, 2023
Blog From Healthy to Heart Condition: A Mother's Account of Her Son's Myocarditis Battle

Nicole Janes, the mother of 14-year-old Cruze Janes, shares their story of the profound impact of his myocarditis diagnosis: “It started on a Sunday and by Friday he needed to be admitted to the hospital for decreased cardiac function.”

May 9, 2023
Blog Finding the Strength to Persevere: A 5-Year Struggle with Chronic Myopericarditis

Five years ago, Newell Rand, aged 23, was diagnosed with chronic myopericarditis after a series of incorrect diagnoses: “The biggest motivation for me is being able to inspire others.”

April 17, 2023
View All Resources
ResourceAn Overview of Cannabidiol as a Multifunctional Drug: Pharmacokinetics and Cellular Effects

Martinez Naya N, Kelly J, Corna G, et al. Molecules. 2024;29(2):473.

January 18, 2024
ResourceCannabidiol As A Potential Treatment For Heart Failure With Preserved Ejection Fraction

Lozano O et al. Heart Failure Society of America Annual Scientific Meeting 2023: ePoster Viewing Session III.

October 7, 2023
ResourceMolecular and Cellular Mechanisms of Action of Cannabidiol

Martinez Naya N, Kelly J, Corna G, et al. Molecules. 2023;28(16):5980.

September 8, 2023
ResourceCannabidiol Inhibits Endothelial-to-mesenchymal Transition and also Promotes the Reverse Process in vitro

Krishnamoorthi MK, Youker KA, Bhimaraj A. Annual Scientific Meeting of the Heart Failure Society of America 2022: Basic and Translational Science Posters.

February 23, 2023

Key International Research and Clinical Collaborators

We collaborate with world-class researchers and clinicians at international centers of excellence and leverage their expertise in drug development, experimental execution, inflammation and fibrosis, the treatment of cardiovascular diseases, and clinical trial protocol design. Our collaborations provide the optimal advice and knowledge platform as we pursue our purpose: heal the heart with innovative science.